A rising number of celebrities have opened up about the harsh realities behind the popular diabetes drug Ozempic, a medication that has quickly become a buzzword in Hollywood and beyond for its unexpected weight loss benefits.
As the hype continues to grow, so do the warnings especially now that a simulation has exposed what the drug truly does to the human body.
Once known strictly as a treatment for type 2 diabetes, Ozempic contains semaglutide, a compound that mimics a hormone responsible for regulating blood sugar.
It helps the pancreas produce more insulin, slows digestion, and reduces appetite. Those effects, in turn, have caused a growing number of people to turn to the drug as a shortcut to rapid weight loss.
But behind the appeal lies a darker reality that even celebrities didn’t anticipate.
Television personality Jeremy Clarkson revealed that after starting Ozempic, he was “frequently sick” and suffered intense nausea for six months before switching to Mounjaro, another semaglutide based drug.
Comedian Amy Schumer shared a similar experience, saying the drug left her bedridden. She too eventually moved to Mounjaro and described it as “great” in comparison.
James Corden admitted the drug made him feel “not hungry,” but noted that it forced him to confront the emotional reasons behind his eating habits.
For Sharon Osbourne, the weight loss came quickly but too quickly. She described how she eventually stopped using the drug, concerned that she was becoming too thin.
Even British actor Stephen Fry spoke out about vomiting up to five times a day while using Ozempic before he ultimately stopped.
Singer Macy Gray added to the list, saying she took the drug ahead of a television appearance but was met with a completely different side effect: severe constipation.
The warnings go beyond celebrity accounts.
Doctors and plastic surgeons have voiced concerns over what’s now being called “Ozempic face” or “Ozempic body” terms describing the hollowed look and sagging skin some users experience after dramatic weight loss. But it’s not just a matter of appearance.
A recent animated simulation from YouTuber Zack D. Films revealed that Ozempic’s appetite-suppressing abilities may come at a physical cost.
The simulation explained that for every ten pounds lost on Ozempic, up to four pounds may come from muscle and bone mass.
Experts warn that some of this tissue may not return even after stopping the drug, potentially leading to long-term health consequences.
The video also highlighted common side effects, including nausea, vomiting, diarrhea, and overall weakness.
The drug’s effect on slowing gastric emptying may help people feel full longer, but it also interferes with digestion in ways that can be uncomfortable or even harmful.
Although Ozempic has become a household name for weight loss, it’s not officially approved for that use. In the United States, the FDA has not greenlit it as a weight-loss drug.
In the UK, the NHS does not prescribe it for that reason either. Instead, other medications like Wegovy, a higher dose version made by the same company are intended for weight management, with Mounjaro expected to follow.
The hype around Ozempic has grown louder, but so has the caution.
As more celebrities continue to speak openly about their personal side effects, and as simulations reveal the full extent of the drug’s impact on the body, a clearer picture is emerging, one that underscores the importance of medical guidance, realistic expectations, and the serious consideration of side effects before chasing rapid weight loss through medication.
Because for some, the transformation is more than just physical. It’s a wake up call.
Featured Image Credit: (YouTube/Zack D. Films)(CanvaPro)
